Does consuming cannabis make COVID vaccines less effective?

COVID vaccines began their roll out with a little rough media coverage, having caused 929 total deaths and 492 cases of COVID-19 in the USA, according to CDC’s Vaccine Adverse Event Reporting System (VAERS.) So, will the COVID vaccines be affected by cannabis use?

It is now known that antibiotics can lower the flu vaccine’s efficiency according to a landmark study published in Cell (1, 2.) But can cannabis consumers keep toking right up to and after the COVID vaccine?

That question is far harder to answer since positive results were predominantly proven based on antibody responses in healthy subjects. Furthermore, the flu vaccine is different than Moderna or Pfizer’s genetic immunizations. So, cannabis may not have a synonymous reaction with different types of COVID vaccines.

Types of COVID vaccines

A few types of COVID vaccines and interventions

• Genetic – This new form of jab uses engineered RNA-like bits of data known as synthetic oligonucleotides, branded as “synthetic mRNA.” These data bits upload a code into the host’s genome. The upload forces the body to produce its own pieces of coronavirus protein. This activates a generic antibody response, displacing IgE as a side effect. (3-7)
• Viral Vector – For its COVID vaccine, AstraZeneca has employed the use of HEK293 immortal cells to grow a virus related to HIV. This virus is then impregnated with Sars-Cov2 spike protein DNA. This engineered intruder forces the body to replicate new RNA that can build an appropriate immune response. (8, 9)
• Attenuated or Inactivated – The flu vaccine is a common example of a ‘live-attenuated’ or ‘inactivated’ immunization. These use a complete virus that is typically rendered non-infectious by chemical sterilization. On the downside, they take a long-time to develop. (4, 10)

It is baseless to claim genetic immunizations do not alter DNA. In other words, please solve the equation encrypted into Markush structure that depicts Formula IA before fact-checking. Photo – Screenshot, US 10,702,600

Forest Ray, Ph.D., stated in Cystic Fibrosis News that Moderna employs more specific gene-editing endonucleases proteins in their other gene therapies. (6) And, Cas9 mRNA is now the most famous of those proteins. Moderna’s Covid vaccine patents do cite an article titled, “RNA – guided human genome engineering via Cas9,” Mali et al. which was published in Science Journal by AAAS in 2013. (US 10,064,959 B2) Despite this controversial treatment, Covid vaccines have been affected by far less regulatory loops than cannabis did during prohibition.

Approval processes

“…remarks still seem radical with the context of Thalidomide’s continued devastation in his country – in this millennium?”

Shockingly, the White House Chief of Staff effectively threatened the FDA Chief into approving Pfizer/BioNTech’s mRNA treatment (11.) It was approved for Emergency Use hours after the FDA Chief’s career was put at stake. Emergency Use allows for the use of an unapproved product – it is not a formal review and approval. (12, 13.) Consider the fact that an FDA regulator born in British Columbia, Canada, Kelsey Frances, is regarded as a hero after she banned Thalidomide from entering USA markets in 1960.

Thalidomide is an immunoregulator drug, with the ability to act on SPALL4 and also spike T cells. This drug tragically caused severe fetal deformities in over 10,000 babies in the late ’50s. This happened due to its improper use as a morning sickness drug in several countries. But, thalidomide is far different than Covid vaccines or mRNA therapy (14.)

Adding to controversy, COVID vaccines are (as of Feb 14, 2020) strongly recommended for pregnant and lactating women according to the American College of Obstetricians and Gynecologists (ACOG) (15.) Their advice goes against the advisement of many other health authorities (16.) As an extreme political example, Brazil’s President Bolsonaro has made noteworthy statements about COVID vaccines according to the AFP (17.) So, do his remarks still seem radical with the context of Thalidomide’s continued devastation in his country – in this millennium (18-20.)

If you turn into a crocodile, it’s your problem.

Jair Bolsonaro on Covid Vaccines. AFP.

Alan, an anonymous eight year old boy severely affected by Thalilamide his mother took by accident in Brazil. Over 100 children have been affected by the drug in this century in Brazil. BBC. 2013 (21.)

Is a vaccine a drug?

Cannabis and COVID vaccines can both prevent symptoms by affecting antibodies. Despite this, scientists are busy answering if mRNA jabs are truly immunizations (22,) rather than immunoregulator drugs. Immunization should facilitate immunity to a disease. But, COVID vaccines do not prevent viral shedding and transmission of SARS-COV2 according to a study published in The Lancet and The New England Journal Of Medicine (NEJM). (22, 23.)

Vaccine development focused on the antibody known as IgG to detect symptom reduction, NEJM. (24) In contradiction to this targeted response, the virus expresses to antibodies IgM<IgA1, but IgG3 only in severe cases. (25-27.) This means the vaccine produces the same protection to the virus as a healthy microbiome. (28)

In summary, mRNA vaccines will trigger an event likewise to an autoimmune disease that helps turn on the cell-division (cancer) switch, in parallel with a discovery published in Science Journal in January, 2021. (10, 29, 30) This is because COVID-19 therapies must agonize CD+ T cells, which no vaccine could do before 2020. (31, 32)

Third lead cause of death versus cannabis

It was medical errors that took third for the leading cause of death in the United States from 2007 to 2013, unofficially ahead of COPD according to John Hopkins. (33)

Despite a lack of research on the topic, COVID vaccines most likely depend on the endocannabinoid system for a proper immune response. However, cannabis strains or products high in caryophyllene can reduce the vaccine’s efficiency (affinity) but can help your body fight against COVID more intelligently (efficacy.) Unlike pharmaceuticals, however, doctors unfortunately possess limited knowledge of cannabis’s drug reactions since those side effects are only slightly more actualized than the North American House Hippo. On the contrary, doctors tend to turn a blind eye to the medicinal properties of cannabis outside of niche circumstances.

Cross-reactions

You can basically do anything with synthetic mRNA…it’s like a computer program. You can even turn someone into a freaking butterfly with the right DNA sequence.

Elon Musk at Axel Springer Award – Musk is partnered with CureVac to build mRNA print factories despite his stance against vaccines. (34)

Oglionucluetide Therapeutics Society (OTS) released a study written by Petra Disterer, Ph.D. in 2017 that laminated a risk for cross-infection from viral vector vaccines. (4) This has now been realized as an increased risk of HIV in the Oxford/Astrazeneca’s vaccine. A study in the Lancet highlighted this risk. (9) However, Disterer, Ph.D. put a greater emphasis of concern on a largely ignored risk for cross-reactivity from mRNA vaccines due to rouge antibody production. They used the relationship between Dengue Fever and Zika Virus as an example.

Now, those cross-reactions have shown up as allergic reactions (dysregulated IgE) in Covid vaccines, NEJM. (35) Bells’ Palsey might fit this causative link given the accuracy of this writing author’s untested hypothesis. It is as follows: a dormant strain of the HPV virus could no longer be kept dormant once the antibody response (epigenome) was altered in individuals with a hypo-IgG, or hyper-IgM, antibody response (SAD). (36, 37) In summary, it is unlikely, but currently unknown, if cannabis can trigger similar cross-reactions and affect Covid vaccines.

Let us know in the comments if you are concerned about the vaccine’s efficiency due to your cannabis consumption. And stay tuned for a deeper dive into specific types of cannabis delivery methods.

Sources

1. Hagan, T., Cortese, M., Rouphael, N., Boudreau, C., Linde, C., Maddur, M. S., Das, J., Wang, H., Guthmiller, J., Zheng, N. Y., Huang, M., Uphadhyay, A. A., Gardinassi, L., Petitdemange, C., McCullough, M. P., Johnson, S. J., Gill, K., Cervasi, B., Zou, J., Bretin, A., Pulendran, B. (2019). Antibiotics-Driven Gut Microbiome Perturbation Alters Immunity to Vaccines in Humans. Cell, 178(6), 1313–1328.e13. doi/10.1016/j.cell.2019.08.010
2. Lynn, M. A., Tumes, D. J., Choo, J. M., Sribnaia, A., Blake, S. J., Leong, L., Young, G. P., Marshall, H. S., Wesselingh, S. L., Rogers, G. B., & Lynn, D. J. (2018). Early-Life Antibiotic-Driven Dysbiosis Leads to Dysregulated Vaccine Immune Responses in Mice. Cell host & microbe, 23(5), 653–660.e5. doi/10.1016/j.chom.2018.04.009
3. US 10,702,600
4. Petra Disterer. 2017. Oligonucleotide therapeutics breaking new ground – modified mRNA vaccines for ZIKA virus demonstrate rapid vaccine development for emerging diseases. OTS.
5. Reardon S. (2020). Step aside CRISPR, RNA editing is taking off. Nature, 578(7793), 24–27. doi.org/10.1038/d41586-020-00272-5
6. Forest Ray. Ph.D. (September 18, 2020.) Moderna, Vertex Team Up to Develop Gene-editing Delivery Techniques. Cystic Fibrosis News Today.
7. CRISPR gene editing. In Wikipedia, The Free Encyclopedia. February 05, 2021. Retrieved 18:03, February 12, 2021
8. WO2018215766A1
9. Buchbinder, S. P., McElrath, M. J., Dieffenbach, C., & Corey, L. (2020). Use of adenovirus type-5 vectored vaccines: a cautionary tale. Lancet (London, England), 396(10260), e68–e69. doi/10.1016/S0140-6736(20)32156-5
10. Ella, R., Vadrevu, K. M., Jogdand, H., Prasad, S., Reddy, S., Sarangi, V., Ganneru, B., Sapkal, G., Yadav, P., Abraham, P., Panda, S., Gupta, N., Reddy, P., Verma, S., Kumar Rai, S., Singh, C., Redkar, S. V., Gillurkar, C. S., Kushwaha, J. S., Mohapatra, S., … Bhargava, B. (2021). Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine, BBV152: a double-blind, randomised, phase 1 trial. The Lancet. Infectious diseases, S1473-3099(20)30942-7. Advance online publication. doi/10.1016/S1473-3099(20)30942-7 
11. JONATHAN LEMIRE, DARLENE SUPERVILLE and MATTHEW PERRONE. Dec. 11, 2020. White House threatens FDA chief’s job over vaccine approval. AP News.
12. Emergency Use Authorization for Vaccines Explained. FDA. Dec 20, 2020.
13. HHS Misused Millions of Dollars Intended for Vaccine Research, Emergency Preparedness. US Office of Special Counsel. Jan 27, 2021
14. National Center for Biotechnology Information (2021). PubChem Compound Summary for CID 5426, Thalidomide. Retrieved February 12, 2021
15. ACOG. (Jan 27, 2020.) Vaccinating Pregnant and Lactating Patients Against COVID-19 Received Feb 14, 2020.
16. UK Gov. (January, 28. 2020.) COVID-19 vaccination: a guide for women of childbearing age, pregnant or breastfeeding
17. Brazil’s Bolsonaro warns virus vaccine can turn people into ‘crocodiles’. (Dec 18, 2020). AFP.
18. Sales Luiz Vianna, F., Kowalski, T. W., Fraga, L. R., Sanseverino, M. T., & Schuler-Faccini, L. (2017). The impact of thalidomide use in birth defects in Brazil. European journal of medical genetics, 60(1), 12–15. doi/10.1016/j.ejmg.2016.09.015
19. Vianna, F. S., Lopez-Camelo, J. S., Leite, J. C., Sanseverino, M. T., Dutra, M., Castilla, E. E., & Schüler-Faccini, L. (2011). Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil. PloS one, 6(7), e21735. doi/10.1371/journal.pone.0021735
20. Schuler-Faccini, L., Soares, R. C., de Sousa, A. C., Maximino, C., Luna, E., Schwartz, I. V., Waldman, C., & Castilla, E. E. (2007). New cases of thalidomide embryopathy in Brazil. Birth defects research. Part A, Clinical and molecular teratology, 79(9), 671–672. doi/10.1002/bdra.20384
21. Angus Crawford. 2013. Brazil’s new generation of Thalidomide babies. BBC.
22. Brown RCH, Kelly D, Wilkinson D, Savulescu J. The scientific and ethical feasibility of immunity passports [published online ahead of print, 2020 Oct 16]. Lancet Infect Dis. 2020;S1473-3099(20)30766-0. doi:10.1016/S1473-3099(20)30766-0
23. Anderson, E. J., Rouphael, N. G., Widge, A. T., Jackson, L. A., Roberts, P. C., Makhene, M., Chappell, J. D., Denison, M. R., Stevens, L. J., Pruijssers, A. J., McDermott, A. B., Flach, B., Lin, B. C., Doria-Rose, N. A., O’Dell, S., Schmidt, S. D., Corbett, K. S., Swanson, P. A., 2nd, Padilla, M., Neuzil, K. M., … mRNA-1273 Study Group (2020). Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults. The New England journal of medicine, 383(25), 2427–2438. doi/10.1056/NEJMoa2028436
24. Walsh, E. E., Frenck, R. W., Jr, Falsey, A. R., Kitchin, N., Absalon, J., Gurtman, A., Lockhart, S., Neuzil, K., Mulligan, M. J., Bailey, R., Swanson, K. A., Li, P., Koury, K., Kalina, W., Cooper, D., Fontes-Garfias, C., Shi, P. Y., Türeci, Ö., Tompkins, K. R., Lyke, K. E., … Gruber, W. C. (2020). Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates. The New England journal of medicine, 383(25), 2439–2450. doi/10.1056/NEJMoa2027906
25. Chakraborty, S., Gonzalez, J., Edwards, K. et al. Proinflammatory IgG Fc structures in patients with severe COVID-19. Nat Immunol 22, 67–73 (2021). doi/10.1038/s41590-020-00828-7
26. French, M. A., & Moodley, Y. (2020). The role of SARS-CoV-2 antibodies in COVID-19: Healing in most, harm at times. Respirology (Carlton, Vic.), 25(7), 680–682. doi/10.1111/resp.13852
27. Korte, W., Buljan, M., Rösslein, M., Wick, P., Golubov, V., Jentsch, J., Reut, M., Peier, K., Nohynek, B., Fischer, A., Stolz, R., Cettuzzi, M., & Nolte, O. (2021). SARS-CoV-2 IgG and IgA antibody response is gender dependent; and IgG antibodies rapidly decline early on. The Journal of infection, 82(1), e11–e14. doi.org/10.1016/j.jinf.2020.08.032  
28. Markowitz, V. M., Chen, I. M., Chu, K., Szeto, E., Palaniappan, K., Grechkin, Y., Ratner, A., Jacob, B., Pati, A., Huntemann, M., Liolios, K., Pagani, I., Anderson, I., Mavromatis, K., Ivanova, N. N., & Kyrpides, N. C. (2012). IMG/M: the integrated metagenome data management and comparative analysis system. Nucleic acids research, 40(Database issue), D123–D129. doi/10.1093/nar/gkr975 
29. Kaur, S. P., & Gupta, V. (2020). COVID-19 Vaccine: A comprehensive status report. Virus research, 288, 198114. doi/10.1016/j.virusres.2020.198114
30. Xu, K., Yin, N., Peng, M., Stamatiades, E. G., Shyu, A., Li, P., Zhang, X., Do, M. H., Wang, Z., Capistrano, K. J., Chou, C., Levine, A. G., Rudensky, A. Y., & Li, M. O. (2021). Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity. Science (New York, N.Y.), 371(6527), 405–410. doi/10.1126/science.abb2683
31. Panagioti, E., Klenerman, P., Lee, L. N., van der Burg, S. H., & Arens, R. (2018). Features of Effective T Cell-Inducing Vaccines against Chronic Viral Infections. Frontiers in immunology, 9, 276. doi/10.3389/fimmu.2018.00276
32. Ott, P. A., & Wu, C. J. (2019). Cancer Vaccines: Steering T Cells Down the Right Path to Eradicate Tumors. Cancer discovery, 9(4), 476–481. https://doi.org/10.1158/2159-8290.CD-18-1357
33. Makary, M. A., & Daniel, M. (2016). Medical error-the third leading cause of death in the US. BMJ (Clinical research ed.), 353, i2139. doi/10.1136/bmj.i2139
34. Presentation of the Axel Springer Award: An Evening for Elon Musk – Mission to Mars.  26.11.2020. PR. Axel Springer. 2017
35. Castells, M. C., & Phillips, E. J. (2020). Maintaining Safety with SARS-CoV-2 Vaccines. The New England journal of medicine, NEJMra2035343. Advance online publication. https://doi.org/10.1056/NEJMra2035343
36. Zhang, W., Xu, L., Luo, T., Wu, F., Zhao, B., & Li, X. (2020). The etiology of Bell’s palsy: a review. Journal of neurology, 267(7), 1896–1905. doi/10.1007/s00415-019-09282-4
37. Theophanous, C., Santoro, J. D., & Itani, R. (2021). Bell’s palsy in a pediatric patient with hyper IgM syndrome and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Brain & development, 43(2), 357–359. doi/10.1016/j.braindev.2020.08.017 
38. Suvarna V. (2010). Phase IV of Drug Development. Perspectives in clinical research, 1(2), 57–60.