The Effects of Masturbation on the Endocannabinoid System

Everyone has an endocannabinoid system and it helps to regulate a lot of the different systems in your body. From the nervous and digestive, endocrine and immune, this system greatly affects many others. It all works through a series of neuroreceptors all over your body and the natural production of proteins that bind to them. 

All sorts of things will make our bodies produce endocannabinoids but many of us do not make enough on our own; that is where cannabis can step in. THC and CBD act as phytocannabinoids, filling in the gap when our body doesn’t produce enough. These days, research is ramping up, but, one area that has yet to be fully explored is the role this system can play when it comes to sex. 

Everyone wants to know how to make the most of their natural endocannabinoid production and it is my pleasure to pass the information along…

If you want to do something that can relieve pain, prevent tumor growth and aid in digestion, go home and masturbate till you get off.

The Study on the effects of masturbation

In 2017, a study was conducted on the effect that masturbating to orgasm had in producing endocannabinoids. Basically, a team of researchers recruited volunteers and took blood samples before and after they got off. The scientists tested their levels of two particular proteins, 2-arachidonoylglycerol (2-AG) and anandamide; curious to see if having an orgasm made any impact. Essentially, this study was meant to explore the role that the endocannabinoid system had when it came to sexual gratification; they were hoping it would lead to some insight into sexual dysfunction. 

The Findings related to masturbation

It was concluded that masturbating to orgasm caused a significant production of 2-AG while other cannabinoids were not affected. In fact, they repeated their study and found the same results. From a research perspective, this is an exciting find because it might help us understand what leads to an orgasm on a molecular level. 

What this might mean for the average person

They say that 70-75% of women cannot reach orgasm from intercourse alone and 10-15% can’t under any circumstances. Having compassion for all the women out there living this way, it gives me great joy to hear that the medical community is looking into it. I’m even happier to hear that cannabis might hold the key to the big O. 

Knowing that our bodies produce this particular protein during an orgasm gives insight. It can provide answers for the medical community looking to understand sexual arousal. Furthermore, It might help us develop ways to make that happen for those of us who struggle to get there. 

2 AG and its effect on the body

In addition to the possibility of a more satisfying society, this study also suggests that masturbation is good for your health. 2 AG is the endocannabinoid most associated with pain relief, proper digestion and tumor growth. So, if you have a medical condition that causes a great deal of pain down there, having an orgasm might help you feel better. An orgasmic release of pain-relieving cannabinoids sounds like nature’s best medicine; especially when it is back by science. 


If you ever got busted masturbating and felt ashamed of what you were doing, you can now let that go. It turns out, masturbation was healthy for you for more reasons than personal development and body consciousness; masturbating to orgasm stimulates more than your reproductive system. Who knew that the orgasmic reward your body naturally produces and the molecular components of cannabis were so closely related? Thanks to this study, now we know. On top of that, we can use this information to help people who do not get to enjoy their full quality of life…

Taking care of your health never felt this good. 


Fuss J1, Bindila L2, Wiedemann K3, Auer MK4, Briken P5, Biedermann SV6. Masturbation to Orgasm Stimulates the Release of the Endocannabinoid 2-Arachidonoylglycerol in Humans. NCBI (Internet). 2017, Nov. 14.

The author would like to thank and acknowledge the invaluable expertise of Dr. Hepburn used for the writing of this article.